Matthew Perry died from “the acute effects of ketamine,” according to the toxicology report from the Los Angeles County Medical Examiner’s Office 

The exact method of intake is unknown. Contributing factors in the “Friends” actor’s death included drowning, coronary artery disease and the effects of buprenorphine (used to treat opioid use disorder). The manner of death was ruled an accident.

Perry had been undergoing ketamine infusion therapy prior to his death, reportedly for depression and anxiety.

The toxicology report adds: “At the high levels of ketamine found in his postmortem blood specimens, the main lethal effects would be from both cardiovascular overstimulation and respiratory depression.”

Perry died on Saturday, Oct. 28, 2023. Authorities arrived at his home in Los Angeles around 4 p.m. and found him in a hot tub, according to the Los Angeles Times.

There were no signs of foul play or drugs at the scene. First responders were called for a cardiac arrest, according to TMZ, which first reported the news.

Perry was best known for playing the hilarious, sarcastic Chandler Bing on “Friends” in the ’90s and early 2000s. He starred in more than 200 episodes of the NBC sitcom across 10 seasons.

We are a family. There is so much to say, but right now we’re going to take a moment to grieve and process this unfathomable loss,” Perry’s “Friends” cast members Jennifer Aniston, Courteney Cox, Lisa Kudrow, Matt LeBlanc and David Schwimmer wrote in a statement following the news of his death.

“He was happy. He was healthy. He had quit smoking. He was getting in shape. He was happy — that’s all I know,” Aniston said.

“I am so grateful for every moment I had with you Matty and I miss you every day,” Cox wrote.